BGC > Buscar Producto > Folinic acid calcium | 1492-18-8

Molecular Formula: C20H21N7O7.Ca
Molecular Weight: 511.51

EINECS:216-082-8
Molecular formula:C20H21N7O7.Ca

Description:
leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.

• Molecular Weight:513.52
• Melting Point:240-250ºC
• Purity:>98%

Molecular Formula:
C20H21N7O7.Ca
Canonical SMILES:
C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.[Ca+2]
InChI:
InChI=1S/C20H23N7O7.Ca.H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;1H2/q;+2;/p-2/t12?,13-;;/m0../s1
InChIKey:
ANIWFDFELBSPJN-RIWFDJIXSA-L
Appearance:
Yellow crystalline powder
Storage: Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ºC). Store protected from light and air.
Synonyms:
IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate

Purity: 95%
Smile code: O=C([C@H](CCC([O-])=O)NC(C1=CC=C(C=C1)NCC2CNC(NC(N)=NC3=O)=C3N2C=O)=O)[O-].[Ca+2]
MDL Number: MFCD08704249
MolFormula: C20H21CaN7O7
MolWeight: 511.5014
Available in stock: 34.403

Smile code:
O=C([C@H](CCC([O-])=O)NC(C1=CC=C(C=C1)NCC2CNC(NC(N)=NC3=O)=C3N2C=O)=O)[O-].[Ca+2]
MDL Number:
MFCD08704249
Purity :
95%
Available in stock:
43.776 g

Appearance:White or light yellow, amorphous or crystalline powder
Content: 97.0% ～ 102.0%
Use: one kind folic acid antidote, API
Peculiarity：Medicine Grade
Packing： 1kg/bag or 25kgs/drum
Min.Order Quantity：100g
Grade Standard：Medicine Grade
Product Specifications：
1.PH：6.0-8.0
2.Heavy metals：NMT 0.005%
3.Water Content：NMT 17.0%
4.Calcium：7.54%~8.14%
5.Standard: USP31
Calcium folinate/leucovorin calcium/Folinic acid is administered at the appropriate time
following methotrexate as part of a total chemotherapeutic plan, where it may `rescue`
bone marrow and gastrointestinal mucosa cells from methotrexate.
There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.

Appearance:White or light yellow, amorphous or crystalline powder
Content: 97.0% ～ 102.0%
Use: one kind folic acid antidote, API
Peculiarity：Medicine Grade
Packing： 1kg/bag or 25kgs/drum
Min.Order Quantity：100g
Grade Standard：Medicine Grade
Product Specifications：
1.PH：6.0-8.0
2.Heavy metals：NMT 0.005%
3.Water Content：NMT 17.0%
4.Calcium：7.54%~8.14%
5.Standard: USP31
Calcium folinate/leucovorin calcium/Folinic acid is administered at the appropriate time
following methotrexate as part of a total chemotherapeutic plan, where it may `rescue`
bone marrow and gastrointestinal mucosa cells from methotrexate.
There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.

Appearance:White or light yellow, amorphous or crystalline powder
Content: 97.0% ～ 102.0%
Use: one kind folic acid antidote, API
Peculiarity：Medicine Grade
Packing： 1kg/bag or 25kgs/drum
Min.Order Quantity：100g
Grade Standard：Medicine Grade
Product Specifications：
1.PH：6.0-8.0
2.Heavy metals：NMT 0.005%
3.Water Content：NMT 17.0%
4.Calcium：7.54%~8.14%
5.Standard: USP31
Calcium folinate/leucovorin calcium/Folinic acid is administered at the appropriate time
following methotrexate as part of a total chemotherapeutic plan, where it may `rescue`
bone marrow and gastrointestinal mucosa cells from methotrexate.
There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.

Appearance:White or light yellow, amorphous or crystalline powder
Content: 97.0% ～ 102.0%
Use: one kind folic acid antidote, API
Peculiarity：Medicine Grade
Packing： 1kg/bag or 25kgs/drum
Min.Order Quantity：100g
Grade Standard：Medicine Grade
Product Specifications：
1.PH：6.0-8.0
2.Heavy metals：NMT 0.005%
3.Water Content：NMT 17.0%
4.Calcium：7.54%~8.14%
5.Standard: USP31
Calcium folinate/leucovorin calcium/Folinic acid is administered at the appropriate time
following methotrexate as part of a total chemotherapeutic plan, where it may `rescue`
bone marrow and gastrointestinal mucosa cells from methotrexate.
There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.